Denial Code 21 (CO-21, PR-21) — Meaning & What to Do

Claim Adjustment Reason Code (CARC)

What denial code 21 means: This is treated as another party's liability (someone else's insurance).
What to do about denial code 21: Confirm whether another party's insurance should be billed.

CO-21 vs PR-21 vs OA-21: what the prefix means

Code on your EOBWhat the prefix meansWho typically pays
CO-21Contractual obligation — the provider writes the amount offUsually not the patient
PR-21Patient responsibilityThe patient
OA-21Other adjustmentOften another payer or plan

The prefix tells you who is expected to absorb the amount; the number (21) tells you why.

Related codes

Keep reviewing your bill

Frequently asked questions about Denial code 21

What does denial code 21 mean on my EOB?

This is treated as another party's liability (someone else's insurance).

What should I do about denial code 21?

Confirm whether another party's insurance should be billed.

Found this code on your bill or EOB?
Upload the document — MD Bill Check decodes every code, checks the math line by line, and explains what's worth questioning.

Check my bill free

Last reviewed 2026-07-07 · MDBillCheck Editorial Team. Plain-English explanations are original wording; always verify the specific reason with your insurer.