CPT Code 45380 — What It Means and What Medicare Pays
CPT code · Procedure · Typically billed in: Hospital or surgery center
Seeing CPT code 45380 on your medical bill?
This code is only one part of the picture — your bill, EOB, insurance adjustments, units, and other charges may affect what you actually owe. MD Bill Check reads the codes on your document, checks the bill in context, and flags items that may be worth reviewing.
What Medicare pays for CPT code 45380
| Where the service is performed | Medicare national average (2025) |
|---|---|
| Doctor's office or clinic (non-facility) | $414.68 |
| Hospital or facility | $192.79 |
The same code pays two different amounts because a facility bills its own separate charge for the room, staff, and equipment — so a hospital visit can produce two lines where an office visit produces one.
Treat this as a reference point, not a ceiling. It is what Medicare pays nationally before any local adjustment — private insurers negotiate their own rates, and a hospital's list price for the same code is often several times higher. A charge far above this number is not automatically an error, but it is a fair thing to ask about.
How many units of CPT code 45380 should appear on one day
If your bill shows more units of CPT code 45380 for a single date of service than that, it is worth asking the billing office to explain the count — duplicate lines and unit-entry mistakes are among the most common medical-billing errors.
Codes normally billed as one with CPT code 45380
Medicare's National Correct Coding Initiative (NCCI) publishes pairs of codes that are considered a single service when performed together. Billing them separately — "unbundling" — inflates a bill.
| Paired code | How the pair is normally treated |
|---|---|
| 12001 Procedure | Separately payable only when a modifier documents a genuinely distinct service |
| 12002 Procedure | Separately payable only when a modifier documents a genuinely distinct service |
| 44140 Surgery | Separately payable only when a modifier documents a genuinely distinct service |
| 93000 Cardiac test | Separately payable only when a modifier documents a genuinely distinct service |
| 93005 Cardiac test | Separately payable only when a modifier documents a genuinely distinct service |
| 95816 Diagnostic test | Separately payable only when a modifier documents a genuinely distinct service |
| 95819 Diagnostic test | Separately payable only when a modifier documents a genuinely distinct service |
| 96360 Infusion | Separately payable only when a modifier documents a genuinely distinct service |
These are 8 of 39 pairs recorded for CPT code 45380. Seeing one of these codes billed alongside CPT code 45380 is not proof of an error — a modifier can legitimately justify it — but it is a specific, answerable question to put to the billing office. What unbundling means, and how to raise it.
Related codes
Keep reviewing your bill
- How to Check a Medical Bill for Errors Before You Pay
- Medical Bill vs EOB: What Is the Difference?
- What Is an Itemized Medical Bill? How to Request One
- Denial and remark codes explained (CARC & RARC)
Frequently asked questions about CPT code 45380
What does CPT code 45380 mean on a medical bill?
Colonoscopy with a biopsy (tissue sample taken). Bills group it under "Procedure", and it is typically provided in this setting: Hospital or surgery center.
How much does CPT code 45380 cost?
Medicare's 2025 national average payment for CPT code 45380 is $414.68 in an office setting and $192.79 when it is performed in a hospital or facility. That figure is a public Medicare benchmark, not a cap on what a provider may charge you — commercial insurers negotiate their own rates and hospital list prices are often several times higher.
How many units of CPT code 45380 can be billed per day?
Medicare's Medically Unlikely Edits normally expect at most 1 unit of CPT code 45380 per patient per day. This is an absolute policy limit — more than 1 unit a day is not payable under any circumstances.
Not sure this charge belongs on your bill?
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